| W | World Outdoor 2021 | 36.84 | Carter, Frater, Blake, Bolt | Jamaica | 8/11/2012 | London, ENG |
| A | American Outdoor 2021 | 37.38 | Demps, Patton, Kimmons, Gatlin | USA national team | 8/10/2012 | London, ENG |
| A | American Outdoor 2021 | 37.38 | Rodgers, Gatlin, Gay, Bailey | USA national team | 5/2/2015 | Nassau, BAH |
| C | College Outdoor 2021 | 37.97 | Ekevwo, Sani-Brown, Holloway, Clark | Florida | 6/7/2019 | Austin, TX |
| U | C-USA championship | 38.89 | Sagesse, West, Carson, Richemond | So. Miss. | 5/13/2018 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | A | Jones | Fuqua | Stewart | Riley | 41.95 | |
| 2 | UTSA |
A | Le Roux | Emerllahu | Masters | Campbell | 41.94 |
| 3 | F.I.U. |
A | Dawson | Watson-Riggins | Grier | Green | 40.99 |
| 4 | SO. MISS. |
A | Miller | Burton | Bienvenue | Williams | 40.62 |
| 5 | NORTH TX |
A | WALKER | JONES | JOHNSON | ANUNAGBA | DNF |
| 6 | UTEP |
A | Smith | Bailey | Powell | Johnson | 40.26 |
| 7 | CHARLOTTE |
A | Robbins | Smith | Ware | Nash | 40.70 |
| 8 | LA TECH |
A | Sapena | Boullion | Melancon | Young | 41.31 |