| W | World Outdoor 2021 | 40.82 | Bartoletta, Felix, Knight, Jeter | USA | 8/11/2012 | London, ENG |
| A | American Outdoor 2021 | 40.82 | Bartoletta, Felix, Knight, Jeter | USA national team | 8/10/2012 | London, ENG |
| C | College Outdoor 2021 | 42.05 | Brisco, Johnson, Misher, Hobbs | L.S.U. | 5/13/2018 | Knoxville, TN |
| U | C-USA championship | 43.42 | Booker, Scott, Layne, Paul | UCF | 5/12/2011 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 4 | RICE |
A | Simms | Coutee-McCullum | Mpagi | Kadmon | 47.03 |
| 5 | UTSA |
A | Adamson | Armstrong | Gruenwald | Chinedu | 46.18 |
| 6 | F.I.U. |
A | Clark | Lubeskie | Declet | Forde-Richards | DNF |
| 7 | MARSHALL |
A | Mitchell | Elysee | Robinson | Bennett | 47.05 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 2 | CHARLOTTE |
A | Boykin-Roach | Petty | Core | Fairman | 46.17 |
| 3 | A | Mensah | Francis | Abrocquah | Obi | 45.98 | |
| 4 | UAB |
A | Sills | Petkov | Tolliver | Dozier | DQ |
| 5 | NORTH TX |
A | Johnson | CHOICE | BURNHAM | SCOTT | 45.37 |
| 6 | SO. MISS. |
A | Flagler | Cato | Green | Benson | 45.54 |
| 7 | UTEP |
A | McFarlane | Jones | Brume | Brown | 45.79 |
| 8 | LA TECH |
A | Harris | Edwards | Scott | Watson | 46.01 |