| W | World Outdoor 2021 | 21.34 | Florence Griffith-Joyner | USA | 9/29/1988 | Seoul, KOR |
| A | American Outdoor 2021 | 21.34 | Florence Griffith Joyner | World Class AC | 9/29/1988 | Seoul, KOR |
| C | College Outdoor 2021 | 22.02 | Kyra Jefferson | Florida | 6/17/2017 | Eugene, OR |
| OV | OVC championship | 23.02 | Naasha Robinson | Tennessee Tech | 5/12/2018 | Cookeville, TN |
| Lane | Athlete | Yr. | Team | Seed |
|---|---|---|---|---|
| 2 | SEALS, KENIA | SO | MURRAY STATE |
24.42 |
| 3 | JAMES, TELIYAH | FR | MURRAY STATE |
24.20 |
| 4 | FRANK, DANIELLE | FR | EASTERN ILLINOIS |
24.00 |
| 5 | PHILLIPS, KENISHA | FR | AUSTIN PEAY |
23.66 |
| 6 | PERRY, QUANTASIA | SO | EASTERN KENTUCKY |
23.96 |
| 7 | SMITH, KAYLA | FR | EASTERN KENTUCKY |
24.15 |
| 8 | KOLLORE, AKIYA | FR | EASTERN ILLINOIS |
24.29 |
| 9 | HARVEY, KILANI | FR | MOREHEAD STATE |
24.50 |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 2 | HENRY, TARYN | FR | TENNESSEE ST. |
26.16 | 2021 Kentucky Invtational |
| 3 | COLEMAN, VIVICA | SO | EASTERN ILLINOIS |
25.18 | Illinois State Invitational |
| 4 | HERRERO-YANEZ, LUCIA | SO | MURRAY STATE |
24.31 | 2021 Kentucky Invtational |
| 5 | HARVEY, KILANI | FR | MOREHEAD STATE |
24.67 | 2021 Kentucky Invtational |
| 6 | FRANK, DANIELLE | FR | EASTERN ILLINOIS |
24.13 | Illinois State Invitational |
| 7 | KOLLORE, AKIYA | FR | EASTERN ILLINOIS |
23.94 | Illinois State Invitational |
| 8 | COGIO, SANDREA | FR | SE MISSOURI |
25.95 | SIUC Bill Cornell Invite |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 2 | TOWNSEND, JANIYAH | FR | TENNESSEE ST. |
24.79 | Georgia Tech Invitational |
| 3 | ROLLINS, AYANNA | JR | JACKSONVILLE ST. |
26.10 | 26.10 North Florida Invite |
| 4 | JAMES, TELIYAH | FR | MURRAY STATE |
24.22 | 2021 Kentucky Invtational |
| 5 | DENNING, JUMYIA | JR | MURRAY STATE |
24.70 | Clark Wood Invitational |
| 6 | SMITH, KAYLA | FR | EASTERN KENTUCKY |
24.20 | Raleigh Relays |
| 7 | PHILLIPS, KENISHA | FR | AUSTIN PEAY |
23.57 | WKU Hilltopper Relays |
| 8 | MCFADDEN, REYNA | SR | TENNESSEE ST. |
26.10 | Georgia Tech Invitational |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 2 | SEALS, KENIA | SO | MURRAY STATE |
24.11 | 2021 Kentucky Invtational |
| 3 | PERRY, QUANTASIA | SO | EASTERN KENTUCKY |
24.05 | Raleigh Relays |
| 4 | RAGGS, ANDRIANNA | SR | JACKSONVILLE ST. |
25.29 | 25.29 Georgia Tech Invitational |
| 5 | MILES, BREANNA | FR | SE MISSOURI |
24.38 | Tennessee Relays |
| 6 | TAYLOR, ADDISON | SO | TENNESSEE-MARTIN |
27.58 | Vanderbilt Black & Gold Invitational |
| 7 | JOHNSON, ZAKIYA | FR | EASTERN ILLINOIS |
24.43 | EIU vs. InSU Dual |
| 8 | COLEMAN, ALYSOUNE | SR | TENNESSEE ST. |
25.81 | Georgia Tech Invitational |
| 9 | MCCULLOUGH, TIMERIA | FR | TENNESSEE-MARTIN |
29.55 | 2021 Joey Haines Invite |