| W | World Outdoor 2021 | 43.03 | Wayde van Niekerk | RSA | 8/14/2016 | Rio de Janeiro, BRA |
| A | American Outdoor 2021 | 43.18 | Michael Johnson | Nike | 8/26/1999 | Seville, ESP |
| C | College Outdoor 2021 | 43.61 | Michael Norman | So. California | 6/8/2018 | Eugene, OR |
| OV | OVC championship | 45.64 | Terrance Branch | SEMO | 1994 |
| Lane | Athlete | Yr. | Team | Seed |
|---|---|---|---|---|
| 2 | ARNOLD, ISHMAEL | SR | BELMONT |
48.83 |
| 3 | JOHNSON, RICKY | FR | EASTERN ILLINOIS |
48.74 |
| 4 | BRETZ, BRANDON | SO | SIU EDWARDSVILLE |
48.55 |
| 5 | BRYANT, NICK | FR | SE MISSOURI |
47.39 |
| 6 | FULLER, QUA'JON | FR | BELMONT |
48.45 |
| 7 | CLAY, DAMIAN | FR | EASTERN ILLINOIS |
48.68 |
| 8 | SCHWAB, COLLIN | JR | SE MISSOURI |
48.75 |
| 9 | MHONDE, TADIWANASHE | JR | EASTERN ILLINOIS |
49.00 |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 2 | BORDEN, BRENT | SO | TENNESSEE-MARTIN |
NT | |
| 3 | SEGREE, BAYLOR | SO | TENNESSEE ST. |
50.32 | 50.32 Margaret Simmons Invite |
| 4 | SCHWAB, COLLIN | JR | SE MISSOURI |
49.01 | 49.01 Ole Miss Classic |
| 5 | SAWYERS, DREW | FR | EASTERN KENTUCKY |
50.23 | EKU Rick Erdmann Twilight |
| 6 | CLAY, DAMIAN | FR | EASTERN ILLINOIS |
48.84 | Bobcat Invitational |
| 7 | BRYANT, NICK | FR | SE MISSOURI |
47.23 | Vanderbilt Black & Gold Invitational |
| 8 | KNIGHT, AUSTIN | SO | TENNESSEE-MARTIN |
53.79 | Margaret Simmons Invite |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 3 | JAMES, DEVIN | FR | TENNESSEE ST. |
50.88 | 2021 Kentucky Invtational |
| 4 | GRIFFIN, HENRY | FR | TENNESSEE-MARTIN |
52.68 | Vanderbilt Black & Gold Invitational |
| 5 | JOHNSON, RICKY | FR | EASTERN ILLINOIS |
49.01 | Big Blue Classic |
| 6 | THOMPSON, MICHAEL | JR | TENNESSEE ST. |
48.44 | UCF Black and Gold Invite |
| 7 | FULLER, QUA'JON | FR | BELMONT |
47.72 | Vanderbilt Black & Gold Invitational |
| 8 | SHEPPARD, ELIJAH | JR | BELMONT |
50.12 | Vanderbilt Black & Gold Invitational |
| Lane | Athlete | Yr. | Team | Seed | Note |
|---|---|---|---|---|---|
| 3 | BELLO, ANTHONY | SR | EASTERN ILLINOIS |
49.27 | Big Blue Classic |
| 4 | BROWN, COLLIN | SR | SIU EDWARDSVILLE |
50.90 | Illinois State Invitational |
| 5 | BRETZ, BRANDON | SO | SIU EDWARDSVILLE |
47.83 | 47.83 Gibson Invitational sponsored by the Terre Haute CVB |
| 6 | MARTIN, COLBY | FR | TENNESSEE-MARTIN |
51.13 | 2021 Joey Haines Invite |
| 7 | ARNOLD, ISHMAEL | SR | BELMONT |
48.38 | Vanderbilt Black & Gold Invitational |
| 8 | MHONDE, TADIWANASHE | JR | EASTERN ILLINOIS |
49.24 | Pacesetter Sports Invitational |