| W | World | 46.78 | Kevin Young | USA | 8/6/1992 | Barscelona, ESP |
| A | American Outdoor | 46.17 | Rai Benjamin | Nike | 8/3/2021 | Tokyo, JPN |
| C | College Outdoor | 47.56 | Kerron Clement | Florida | 6/11/2005 | Sacramento, CA |
| M | Meet | 52.54 | Mychal Word | Shreveport Speed | 2016 |
| Lane | # | Athlete | Yr. | Team | Seed |
|---|---|---|---|---|---|
| 2 | 32 | WHITE, DEREK | SO | ST. THOMAS (TEX.) |
1:04.50 |
| 3 | 93 | JAMIERSON, DAYTON | SR | XAVIER-LOUISIANA |
58.12 |
| 4 | 3 | CLASE, BRENCE | UNA | UNAT-ST. THOMAS (TEX.) | 55.40 |
| 5 | 431 | ALLEN, TYVONNE | SR | WILEY |
55.81 |
| 6 | 75 | MACKENZIE, MAURICKA | SR | XAVIER-LOUISIANA |
1:03.13 |
| 7 | 127 | CARPENTER, CAYDON | SO | XAVIER-LOUISIANA |
NT |
| 8 | 447 | FISHER, BRIAN | FR | WILEY |
NT |
| Lane | # | Athlete | Yr. | Team | Seed |
|---|---|---|---|---|---|
| 2 | 309 | FRANCIS, DMARI | FR | MCNEESE STATE |
NT |
| 3 | 333 | KEENE, E'DARYUS | FR | PRAIRIE VIEW |
NT |
| 4 | 302 | MOHAMED, OBIED | SO | MCNEESE STATE |
NT |
| 5 | 446 | GARRETT, RONALD | FR | WILEY |
NT |
| 6 | 560 | LEWIS, CHAUNKIVEON | FR | TEXAS SOUTHERN |
NT |
| 7 | 109 | MORRIS, DAVID | FR | XAVIER-LOUISIANA |
NT |
| 8 | 542 | SMITH, HILTON | SO | TEXAS SOUTHERN |
NT |