| Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | |
|---|---|---|---|---|---|---|---|
| 1 | LUCY BECKHAM | A | Goldman | Gramiccioni | Hopson | Kennedy | 3:59.38 |
| 2 | WEST FLORENCE | A | Webb | Young | Johnson | Burroughs | 4:02.38 |
| 3 | GOOSE CREEK | A | Crawford | Horne | Manigualt-Garrett | Freeman | 4:08.33 |
| 4 | ST. JAMES | A | Schubiger | Schubiger | Shuping | Mention | 4:17.39 |
| 5 | BERKELEY | A | Aladi | Butler | Cooper | Quick | 4:20.64 |
| 6 | SOCASTEE | A | Lange | Holladay | Sudo | James | 4:24.15 |
| 7 | MYRTLE BEACH | A | Clements | Suriol-Gaul | Wallace | Waterman | 4:27.72 |