3 turn Stagger start
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed |
|---|---|---|---|---|---|---|---|
| 1 | SOCASTEE | A | Livingston | Coudill | Lloyd | Wachter | 3:50.92 |
| 2 | MYRTLE BEACH | A | Bryant | Miller | Wheeler | Mullins | DNS |
| 3 | NORTH MYRTLE BEACH | A | Jaden | Camren | Jerell | Ny'Ray | 3:31.61 |
| 4 | BERKELEY | A | Robinson | Prioleau | tfank | Jacobs | 3:28.45 |
| 5 | GOOSE CREEK | A | Wilder | Bean | Horne | Rouse | 3:30.99 |
| 6 | LUCY BECKHAM | A | Rasgo | Price | Nelson | McLester | 3:32.57 |
| 7 | ST. JAMES | A | Long | Ochoa | De Los Santos | Alot | 3:33.85 |
| 8 | WEST FLORENCE | A | Carter | Cashin | Graham | Johnson | 3:34.02 |