| W | World | 46.78 | Kevin Young | USA | 8/6/1992 | Barcelona, ESP |
| A | American | 46.78 | Kevin Young | Foot Locker AC | 8/6/1992 | Barcelona, ESP |
| C | College Outdoor | 47.56 | Kerron Clement | Florida | 6/11/2005 | Sacramento, CA |
| VT | Vanderbilt Track | 48.29 | Kerron Clement | Florida | 5/15/2005 |
| Athlete | Yr. | Team | Seed | |
|---|---|---|---|---|
| 1 | WAYNE NEWMAN | SR | LIPSCOMB | 51.59 |
| 2 | JERMAINE WADE | SR | SONIC RACING | 52.18 |
| 3 | JUSTIN AGUSTIN | SR | ILLINOIS ST. | 52.92 |
| 4 | JONATHAN HAYDEN | SR | W. KY. | 53.10 |
| 5 | TRE BROWN | SR | OAKLAND | 53.12 |
| 6 | CHRISTIAN CRENSHAW | SR | BELMONT | 53.40 |
| 7 | MICHAEL JOPES | SR | ILLINOIS ST. | 53.50 |
| 8 | WILLIAM WALKER | JR | KENTUCKY | 53.64 |
| 9 | DENZEL VILLAMAN | JR | W. KY. | 54.84 |
| 10 | ANDREW STORM | SO | OAKLAND | 54.90 |
| 11 | JACOB SNYDER | FR | LIPSCOMB | 55.69 |
| 12 | EVAN TANDY | SR | HILLSDALE | 56.00 |
| 13 | GREG CANTRELL | JR | M.T.S.U. | 56.08 |
| 14 | DAVID DOWNEY | SO | HILLSDALE | 57.50 |
| 15 | ALEC TANKSLEY | FR | W. KY. | NT |
| 16 | KHRISTIAN VICKERS | FR | BELMONT | NT |
| 17 | MARCUS NELLUM | FR | OAKLAND | NT |